Detalhe da pesquisa
1.
Low-dose Gene Therapy Reduces the Frequency of Enzyme Replacement Therapy in a Mouse Model of Lysosomal Storage Disease.
Mol Ther
; 24(12): 2054-2063, 2016 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-27658524
2.
Efficacy, pharmacokinetics, and safety in the mouse and primate retina of dual AAV vectors for Usher syndrome type 1B.
Mol Ther Methods Clin Dev
; 28: 396-411, 2023 Mar 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-36910588
3.
Therapeutic homology-independent targeted integration in retina and liver.
Nat Commun
; 13(1): 1963, 2022 04 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-35414130
4.
Liver-Directed Adeno-Associated Virus-Mediated Gene Therapy for Mucopolysaccharidosis Type VI.
NEJM Evid
; 1(7): EVIDoa2200052, 2022 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-38319253
5.
Glioblastoma-derived leptin induces tube formation and growth of endothelial cells: comparison with VEGF effects.
BMC Cancer
; 11: 303, 2011 Jul 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-21771332
6.
Low incidence of hepatocellular carcinoma in mice and cats treated with systemic adeno-associated viral vectors.
Mol Ther Methods Clin Dev
; 20: 247-257, 2021 Mar 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33473358
7.
miR-20b modulates VEGF expression by targeting HIF-1 alpha and STAT3 in MCF-7 breast cancer cells.
J Cell Physiol
; 224(1): 242-9, 2010 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-20232316
8.
Expression of angiogenic regulators, VEGF and leptin, is regulated by the EGF/PI3K/STAT3 pathway in colorectal cancer cells.
J Cell Physiol
; 221(1): 189-94, 2009 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-19492417
9.
Current Status on Clinical Development of Adeno-Associated Virus-Mediated Liver-Directed Gene Therapy for Inborn Errors of Metabolism.
Hum Gene Ther
; 30(10): 1204-1210, 2019 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-31517544
10.
Non-clinical Safety and Efficacy of an AAV2/8 Vector Administered Intravenously for Treatment of Mucopolysaccharidosis Type VI.
Mol Ther Methods Clin Dev
; 6: 143-158, 2017 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-28932756
11.
Prevalence of anti-adeno-associated virus serotype 8 neutralizing antibodies and arylsulfatase B cross-reactive immunologic material in mucopolysaccharidosis VI patient candidates for a gene therapy trial.
Hum Gene Ther
; 26(3): 145-52, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25654180
12.
Similar therapeutic efficacy between a single administration of gene therapy and multiple administrations of recombinant enzyme in a mouse model of lysosomal storage disease.
Hum Gene Ther
; 25(7): 609-18, 2014 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-24725025
13.
Gene therapy for mucopolysaccharidosis type VI is effective in cats without pre-existing immunity to AAV8.
Hum Gene Ther
; 24(2): 163-9, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23194248
14.
Metformin inhibits leptin-induced growth and migration of glioblastoma cells.
Oncol Lett
; 4(5): 1077-1081, 2012 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-23162655
15.
Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.
Eur J Cancer
; 47(10): 1578-84, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21353530
16.
Obesity hormone leptin induces growth and interferes with the cytotoxic effects of 5-fluorouracil in colorectal tumor stem cells.
Endocr Relat Cancer
; 17(3): 823-33, 2010 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-20603394
17.
Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy.
Brain Pathol
; 20(2): 481-9, 2010 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-19775291